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CTSN Primary Outcome Papers and Late Breaking Science
Publication	Journal
Transcatheter or Surgical Replacement for Failed Bioprosthetic Aortic Valves	JAMA Cardiology
Clinical Trial Diversity, Equity & Inclusion: Roadmap of the Cardiothoracic Surgical Trials Network	Annals of Thoracic Surgery
Intravenous aviptadil and remdesivir for treatment of COVID-19-associated hypoxaemic respiratory failure in the USA (TESICO): a randomised, placebo-controlled trial	The Lancet Respiratory Medicine
Pacemaker Implantation Associated with Tricuspid Repair in the Setting of Mitral Valve Surgery: Insights from a Cardiothoracic Surgical Trials Network Randomized Trial	The Journal of Thoracic and Cardiovascular Surgery
Intimal hyperplasia, saphenous vein graft disease, and clinical outcomes: Insights from the CTSN VEST randomized trial	The Journal of Thoracic and Cardiovascular Surgery
Tixagevimab–cilgavimab for treatment of patients hospitalised with COVID-19: a randomised, double-blind, phase 3 trial	The Lancet Respiratory Medicine
Efficacy and Safety of Ensovibep for Adults Hospitalized With COVID-19 : A Randomized Controlled Trial	Annals of Internal Medicine
A Randomized Trial of Mesenchymal Stromal Cells for Moderate to Severe ARDS from COVID-19	American Journal of Respiratory and Critical Care Medicine
External Support for Saphenous Vein Grafts in Coronary Artery Bypass Surgery: A Randomized Clinical Trial	JAMA Cardiology
Concomitant Tricuspid Repair in Patients with Degenerative Mitral Regurgitation	The New England Journal of Medicine
Efficacy and safety of two neutralising monoclonal antibody therapies, sotrovimab and BRII-196 plus BRII-198, for adults hospitalised with COVID-19 (TICO): a randomised controlled trial	The Lancet Infectious Diseases
A Neutralizing Monoclonal Antibody for Hospitalized Patients with COVID-19	The New England Journal of Medicine
Intramyocardial Injection of Mesenchymal Precursor Cells and Successful Temporary Weaning From Left Ventricular Assist Device Support in Patients With Advanced Heart Failure: A Randomized Clinical Trial	The Journal of the American Medical Association
Effect of Cerebral Embolic Protection Devices on CNS Infarction in Surgical Aortic Valve Replacement: A Randomized Clinical Trial	The Journal of the American Medical Association
Two-Year Outcomes of Surgical Treatment of Moderate Ischemic Mitral Regurgitation	The New England Journal of Medicine
Hybrid Coronary Revascularization for the Treatment of Multivessel Coronary Artery Disease: A Multicenter Observational Study	Journal of the American College of Cardiology
Rate Control versus Rhythm Control for Atrial Fibrillation after Cardiac Surgery	The New England Journal of Medicine
Two-Year Outcomes of Surgical Treatment of Severe Ischemic Mitral Regurgitation	The New England Journal of Medicine
Predicting recurrent mitral regurgitation after mitral valve repair: A difficult endeavor and a necessity	The Journal of thoracic and cardiovascular surgery
Surgical Ablation of Atrial Fibrillation during Mitral-Valve Surgery	The New England Journal of Medicine
Mesenchymal precursor cells as adjunctive therapy in recipients of contemporary left ventricular assist devices	Circulation - American Heart Association
Surgical Treatment of Moderate Ischemic Mitral Regurgitation	The New England Journal of Medicine
Management practices and major infections after cardiac surgery	Journal of the American College of Cardiology
Mitral-valve repair versus replacement for severe ischemic mitral regurgitation	The New England Journal of Medicine

Publication	Journal
Association of Tricuspid Regurgitation with Clinical Events and Quality of Life after Surgery for Severe Ischemic Mitral Regurgitation	Journal of Thoracic and Cardiovascular Surgery Structural and Endovascular
Cardiac Surgery After Transcatheter Aortic Valve Replacement: Trends and Outcomes	The Annals of Thoracic Surgery
Viral and Host Factors Are Associated With Mortality in Hospitalized Patients With COVID-19	Clinical Infectious Diseases
Early trajectories of virological and immunological biomarkers and clinical outcomes in patients admitted to hospital for COVID-19: an international, prospective cohort study	Lancet Microbe
Response Regarding: "Clinical Implication to Predict New-Onset Atrial Fibrillation After Cardiac Surgery"	Journal of Surgical Research
Permanent Pacemaker Implantation and Long-Term Outcomes of Patients Undergoing Concomitant Mitral and Tricuspid Valve Surgery	Journal of the American College of Cardiology
Effect of Neutralizing Monoclonal Antibody Treatment on Early Trajectories of Virologic and Immunologic Biomarkers in Patients Hospitalized With COVID-19	The Journal of Infectious Disease
Infarct-related structural disconnection and delirium in surgical aortic valve replacement patients	Annals of Clinical and Translational Neurology
Prospective Study of Risk Factors for Postoperative Atrial Fibrillation After Cardiac Surgery	Journal of Surgical Research
The impact of perioperative stroke and delirium on outcomes after surgical aortic valve replacement	The Journal of Thoracic and Cardiovascular Surgery
Anticoagulation for atrial fibrillation after cardiac surgery: Do guidelines reflect the evidence?	The Journal of Thoracic and Cardiovascular Surgery
Comment on: Efficacy and Safety of Ensovibep for Adults Hospitalized With COVID-19	Annals of Internal Medicine
Efficacy and Safety of Ensovibep for Adults Hospitalized With COVID-19	Annals of Internal Medicine
The Association of Baseline Plasma SARS-CoV-2 Nucleocapsid Antigen Level and Outcomes in Patients Hospitalized With COVID-19	Annals of Internal Medicine
Evaluating Primary Endpoints for COVID-19 Therapeutic Trials to Assess Recovery	American Journal of Respiratory and Critical Care Medicine
Responses to a Neutralizing Monoclonal Antibody for Hospitalized Patients With COVID-19 According to Baseline Antibody and Antigen Levels: A Randomized Controlled Trial	Annals of Internal Medicine
Lessons from an international trial evaluating vaccination strategies for recovered inpatients with COVID-19 (VATICO)	Med
Re-analysis of the Effect of Coronary Artery Bypass Surgery in Patients With Left Ventricular Dysfunction	Journal of Cardiac Failure
Tricuspid Repair in Patients with Degenerative Mitral Regurgitation	The New England Journal of Medicine
Rationale and Design of a Randomized Trial Evaluating an External Support Device for Saphenous Vein Coronary Grafts	American Heart Journal
Design and implementation of an international, multi-arm, multi-stage platform master protocol for trials of novel SARS-CoV-2 antiviral agents: Therapeutics for Inpatients with COVID-19 (TICO/ACTIV-3)	Clinical Trials
Reply from authors: Discordant trial results lead to disproportionate learnings	The Journal of Thoracic and Cardiovascular Surgery
Risk for non-home discharge following surgery for ischemic mitral valve disease	The Journal of Thoracic and Cardiovascular Surgery
Transcatheter mitral valve repair for functional mitral regurgitation: Evaluating the evidence	The Journal of Thoracic and Cardiovascular Surgery
Trends in MitraClip, mitral valve repair, and mitral valve replacement from 2000 to 2016	The Journal of Thoracic and Cardiovascular Surgery
Progression of Tricuspid Regurgitation After Surgery for Ischemic Mitral Regurgitation	Journal of the American College of Cardiology
Strategies of Wait-listing for Heart Transplant vs Durable Mechanical Circulatory Support Alone for Patients With Advanced Heart Failure	JAMA Cardiology
Cost-effectiveness of coronary artery bypass grafting plus mitral valve repair versus coronary artery bypass grafting alone for moderate ischemic mitral regurgitation	The Journal of Thoracic and Cardiovascular Surgery
Randomized Trials in Cardiac Surgery: JACC Review Topic of the Week	Journal of the American College of Cardiology
Impact of Aortic Atherosclerosis Burden on Outcomes of Surgical Aortic Valve Replacement	The Annals of Thoracic Surgery
Incidence and Risk Factors for Permanent Pacemaker Implantation Following Mitral or Aortic Valve Surgery	Journal of the American College of Cardiology
Sex-Based Differences in Outcomes After Mitral Valve Surgery for Severe Ischemic Mitral Regurgitation: From the Cardiothoracic Surgical Trials Network	Heart Failure - JACC
Pacemaker Implantation After Mitral Valve Surgery With Atrial Fibrillation Ablation	Journal of the American College of Cardiology
Biatrial maze procedure versus pulmonary vein isolation for atrial fibrillation during mitral valve surgery: New analytical approaches and end points	The Journal of Thoracic and Cardiovascular Surgery
Cost-Effectiveness of Mitral Valve Repair Versus Replacement for Severe Ischemic Mitral Regurgitation: A Randomized Clinical Trial From the Cardiothoracic Surgical Trials Network	American Heart Association Journals
Cost-effectiveness analysis in cardiac surgery: A review of its concepts and methodologies	The Journal of Thoracic and Cardiovascular Surgery
Secondary surgical-site infection after coronary artery bypass grafting: A multi-institutional prospective cohort study	The Journal of Thoracic and Cardiovascular Surgery
A Prospective Multi-Institutional Cohort Study of Mediastinal Infections After Cardiac Operations	The Annals of Thoracic Surgery
A multi-institutional cohort study confirming the risks of Clostridium difficile infection associated with prolonged antibiotic prophylaxis	The Journal of Thoracic and Cardiovascular Surgery
Probability of atrial fibrillation after ablation: Using a parametric nonlinear temporal decomposition mixed effects model	Statistical Methods in Medical Research
The Cardiothoracic Surgical Trials Network: Implications for clinical practice	The Journal of Thoracic and Cardiovascular Surgery
Pneumonia after cardiac surgery: Experience of the National Institutes of Health/Canadian Institutes of Health Research Cardiothoracic Surgical Trials Network	The Journal of Thoracic and Cardiovascular Surgery
Response by Capoulade et al to Letter Regarding Article, "Impact of Left Ventricular to Mitral Valve Ring Mismatch on Recurrent Ischemic Mitral Regurgitation After Ring Annuloplasty"	American Heart Association Journals
Predicting recurrent mitral regurgitation after mitral valve repair: A difficult endeavor and a necessity	The Journal of Thoracic and Cardiovascular Surgery
Cardiothoracic Surgical Trials Network (CTSN) Investigators. Impact of Left Ventricular to Mitral Valve Ring Mismatch on Recurrent Ischemic Mitral Regurgitation After Ring Annuloplasty	American Heart Association Journals
Rate Control or Rhythm Control for Atrial Fibrillation after Heart Surgery	The New England Journal of Medicine
Rate Control or Rhythm Control for Atrial Fibrillation after Heart Surgery	The New England Journal of Medicine
Surgery for Severe Ischemic Mitral Regurgitation	The New England Journal of Medicine
Identifying patients who benefit from restrictive annuloplasty in ischemic mitral regurgitation: An elusive yet essential quest! Toward a patient-tailored approach	The Journal of Thoracic and Cardiovascular Surgery
Diabetes and the Association of Postoperative Hyperglycemia with Clinical and Economic Outcomes in Cardiac Surgery	Diabetes Care
Antibiotic prophylaxis and risk of Clostridium difficile infection after coronary artery bypass graft surgery	The Journal of Thoracic and Cardiovascular Surgery
Cardiothoracic Surgical Trials Network: Evidence-based surgery	The Journal of Thoracic and Cardiovascular Surgery
Changes in Risk Profile and Outcomes of Patients Undergoing Surgical Aortic Valve Replacement From the Pre- to Post-Transcatheter Aortic Valve Replacement Eras	The Annals of Thoracic Surgery
Severe ischemic mitral regurgitation: Repair or replace?	The Journal of Thoracic and Cardiovascular Surgery
Severe ischemic mitral regurgitation: Repair or replace?	The Journal of Thoracic and Cardiovascular Surgery
Instrumental variable methods in clinical research	The Journal of Thoracic and Cardiovascular Surgery
Repair or replace for severe ischemic mitral regurgitation: prospective randomized multicenter data	Annals of Cardiothoracic Surgery
We need a better way to repair ischemic mitral regurgitation	The Journal of Thoracic and Cardiovascular Surgery
Surgical Ablation for Atrial Fibrillation	The New England Journal of Medicine
Therapy for secondary mitral regurgitation: time to 'cut the chord'?	Heart
Repair or observe moderate ischemic mitral regurgitation during coronary artery bypass grafting? Prospective randomized multicenter data	Annals of Cardiothoracic Surgery
Surgical treatment of moderate ischemic mitral regurgitation	The New England Journal of Medicine
Costs associated with health care-associated infections in cardiac surgery	Journal of the American College of Cardiology
Readmissions after cardiac surgery: experience of the National Institutes of Health/Canadian Institutes of Health research cardiothoracic surgical trials network	The Annals of Thoracic Surgery
Surgery for severe ischemic mitral regurgitation	The New England Journal of Medicine
Asymmetric versus symmetric tethering patterns in ischemic mitral regurgitation: geometric differences from three-dimensional transesophageal echocardiography	Journal of the American Society of Echocardiography
Blood transfusion and infection after cardiac surgery	The Annals of Thoracic Surgery
Weighting composite endpoints in clinical trials: essential evidence for the heart team	The Annals of Thoracic Surgery
Optimal surgical management of severe ischemic mitral regurgitation: to repair or to replace?	The Journal of Thoracic and Cardiovascular Surgery
Functional, ischemic mitral regurgitation: to repair or not to repair?	American Heart Association Journals
Design, rationale, and initiation of the Surgical Interventions for Moderate Ischemic Mitral Regurgitation Trial: a report from the Cardiothoracic Surgical Trials Network	The Journal of Thoracic and Cardiovascular Surgery
Building an infrastructure for clinical trials in cardiac surgery	The Journal of Thoracic and Cardiovascular Surgery
Designing comparative effectiveness trials of surgical ablation for atrial fibrillation: experience of the Cardiothoracic Surgical Trials Network	The Journal of Thoracic and Cardiovascular Surgery
Innovative clinical trial design in cardiac surgery	Seminars in Thoracic and Cardiovascular Surgery
The Cardiothoracic Surgery Network: randomized clinical trials in the operating room	The Journal of Thoracic and Cardiovascular Surgery
Randomized trials in surgery	Surgery
Assessing technological change in cardiothoracic surgery	Seminars in Thoracic and Cardiovascular Surgery

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